CH370/387D -Syllabus and Links to Lecture Notes (revised 1/30/07)
| Date | Topic/ Link to Lecture Notes | Chapter | Other |
| Jan. 16 | No classes - University closed (ice storm) | ||
| Jan. 18 | Introduction: Quiz - Review of a.a. and proteins | 1 | |
| Jan. 23 | Protein Structure: 2o, 3o, 4o Protein Folding | 1 | |
| Jan. 25 | Sequence Alignments / terms / Software BLAST (PPT seq alignments) | 1,3,4 | |
| Jan. 30 | Protein Expression and Purification Chromatography / Gel filtration | 5 | |
| Feb. 1 | Spectroscopy / Fluorescence (slides) | 8,9,11 | |
| Feb. 6 | Review: Physical and Structural Properties of Nucleic Acids - use of DNA microarrays - HW-1 due | 1,3,4 | |
| Feb. 8 | *** EXAM I *** (in WCH 1.120) Review notes KEY | ||
| Feb. 13* | Use of Radioisotopes (Röntgen and X-rays) Slides | -- | |
| Feb. 15 | Electrophoresis IEF (more slides) | 5 | |
| Feb. 20 | Centrifugation / Ultracentrifugation - sed. vel. (lect notes) | 5,13 | |
| Feb. 22 | Sedimentation Equilibrium - applications (*see below) WC-1 due | 5,13 | |
| Feb. 27 | Light Scattering (pdf) - static and dynamic (lect notes) | 7 | |
| Mar. 1 | CD (tutorial) (tutorial) | 10 | |
| Mar. 6 | Mass Spectroscopy (tutorials / lecture notes) | 15 | |
| Mar. 8 | Proteomics: Basic Tutorial - Lecture notes - Proteomics links - MS in Proteomics Review | 15 | |
| Mar. 12-16 | ***** SPRING BREAK ***** | ||
| Mar. 20 | / Catch Up - Exam 2 Review notes (no MS on exam) HW-2 due Key | ||
| Mar. 22 | ***** EXAM II **** (in WCH 1.120) Review notes Key | ||
| Mar. 27** | Ligand Binding - Introduction (Equations from KJ) slides | 14 | |
| Mar. 29 | Ligand Binding - Applications - Isothermal Titration Calorimetry ITC materials ITC lect slides | 2,14 | |
| Apr. 3 | Ligand Binding - Appl- Surface Plasmon Res (SPR1, SPR2) slides notes | 2,14 | |
| Apr. 5 | Intro. to the PDB, Image Formation, and Structure Detn.- overveiw; PPT | -- | |
| Apr. 10 | Nuclear Magnetic Resonance - 1 (Dr. Hoffman) | 12 | |
| Apr. 12 | Nuclear Magnetic Resonance - 2 | 12 | |
| Apr. 17 | Nuclear Magnetic Resonance - 3 | 12 | |
| Apr. 19 | X-ray Crystallography -1 PPT WC-2 due | 6 | |
| Apr. 24 | X-ray Crystallography -2 PPT | 6 | |
| Apr. 26 | Electron Microscopy HW-3 due | ||
| May 1 | ***** EXAM III *** (in GEO 2.324) | ||
| May 3 | Review / Wrap Up / Final Sampler | ||
| MAY 9 | Comp. FINAL EXAM: 7:00-10:00 WEL 3.502 |
*February 12 - Last day to drop without possible academic penalty.
**March 26 - Last day undergraduates can drop a course for non-academic reasons, with the Dean's permission.
*HW-2: Use this for #1; F - fv = m(dv/dt) solves to v = (F/f) [ 1 - exp(-ft/m)]. Calc. "s" for sed. velocity data and "M" from sedimentation equilibrium data.
