CH370 -Syllabus and Links to Lecture Notes
| Date | Topic/ Link to Lecture Notes | Chapter | Other |
| Aug. 27 | Introduction: Quiz - Review of ionic properties of a.a. and proteins | 1 | |
| Sept. 1 | Protein Structure: 2o, 3o, 4o Protein Folding | 1,3,4 | |
| Sept. 3 | Introduction to NCBI / PDB / PyMOL (see Links for tutorial) | ||
| Sept. 8 | Sequence Alignments (notes) / terms / BLAST comp tools | ||
| Sept. 10 | Protein Expression and Purification : Solubility / Chromatography / Gel filtration (notes) | 5 | |
| Sept. 15 | Spectroscopy / Fluorescence (notes) (Trp F) (tutorial) (prob) | 8,9,11 | |
| Sept. 17 | Physical and Structural Properties of Nucleic Acids DNA Methods: Sequencing | 1,3,4 | |
| Sept. 22 | DNA microarrays / Applications - Review: HW-1 due (8:45) | ||
| Sept. 24* | *** EXAM I *** (in HMA = Hogg Aud.)) Exam KEY | -- | |
| Sept. 29 | Discovery of X-rays and Radioactivity (Rontgen and X-rays) slides | -- | |
| Oct. 1 | Use of Radioisotopes and Counting slides | ||
| Oct. 6 | Electrophoresis IEF (primer on Protein Electrophoresis) DNA Elect On-line animations 1 2 BLAST due | 5 | |
| Oct. 8 | Centrifugation / Ultracentrifugation - Sed. Velocity (s) slides | 5,13 | |
| Oct. 13 | Sedimentation Equilibrium / applications | 5,13 | |
| Oct. 15 | Circular Dichroism CD (tutorial) (tutorial) Lect slides / Light Scattering (pdf) - static and dynamic (lect notes) (Wyatt on theory) | 7,10 | |
| Oct. 20 | Mass Spectroscopy (tutorials / lecture notes) / MS + Proteomics: | 15 | |
| Oct. 22 | / HW-2 due KEY pt1 pt2 | ||
| Oct. 27 | ***** EXAM II **** (in HMA) Review Summary Exam KEY | ||
| Oct. 29 | Ligand Binding - Introduction slides (Ken J. Eqns Summary) | 2,14 | |
| Nov. 3 | Ligand Binding - Meas. K - Isothermal Titration Calorimetry ITC and Surface Plasmon Res (SPR1, SPR2, Dr.DH's notes (also see April 2nd lecture slides) | 2,14 | |
| Nov. 5 | Kinetics WC due Intro. to the PDB, Image Formation notes | 2,14 | |
| Nov. 10 | Electron Microscopy - EM; other imaging methods notes | ||
| Nov. 12 | X-ray Crystallography -1 notes HW-3 (due 4/30) | 6 | |
| Nov. 17 | X-ray Crystallography -2 notes | 6 | |
| Nov. 19 | Nuclear Magnetic Resonance - 1 notes 1 | 12 | |
| Nov. 24 | Nuclear Magnetic Resonance - 2 / MRI / notes2 (more NMR notes) HW-3 due (Key) | 12 | |
| Nov. 26 | ****** THANKSGIVING ****** | ||
| Dec. 1 | ***** EXAM III *** (A-L in WEL 2.304 / M-Z in JGB 2.102) Review Sum Exam KEY | ||
| Dec 3 | Review Wrap Up / Final Exam Format and Sample / Sample Ans sheet and equations given | ||
| Dec 12 | Comp. FINAL EXAM: 9:00-12:00 | ||
*September 23 - Last day to drop without possible academic penalty.
**October 21 - Last day undergraduates can drop a course for non-academic reasons, with the Dean's permission.
*HW-2: Use this for #1; F - fv = m(dv/dt) solves to v = (F/f) [ 1 - exp(-ft/m)]. Calc. "s" for sed. velocity data and "M" from sedimentation equilibrium data.
