CH370 -Syllabus and Links to Lecture Notes
| Date | Topic/ Link to Lecture Notes | Chapter | Other |
| Aug. 26+ | Introduction: Quiz - Review of ionic properties of a.a. and proteins pKa, pI DH notes | 1 | |
| Aug 31+ | Protein Structure: 2o, 3o, 4o Protein Folding DH notes | 1,3,4 | |
| Sept. 2 | Physical and Structural Properties of Nucleic Acids | ||
| Sept. 7 | DNA Sequencing notes | ||
| Sept. 9 | Introduction to NCBI / PDB Sequence Alignments (notes) / terms / BLAST comp tools | ||
| Sept. 14 | Protein Expression and Purification : Solubility / Chromatography (notes) HW-1 | 5 | |
| Sept. 16 | Light and Matter Spectroscopy / Fluorescence FRET (notes) (Trp F) (tutorial) | 8,9,11 | |
| Sept. 21 | DNA Methods: - Review: HW-1 due (8:30) KEY HW-1 | ||
| Sept. 23* | *** EXAM I *** Review Summary KEY NOTE: Exam in GSB 2.124 | -- | |
| Sept. 28 | DNA microarrays / Applications | -- | |
| Sept 30 | Discovery of X-rays and Radioactivity (Rontgen and X-rays) notes / slides | ||
| Oct. 5 | Use of Radioisotopes and Counting (cont'd) | ||
| Oct. 7 | Electrophoresis IEF (primer on Protein Electrophoresis) DNA Electrophoresis On-line animations 1 2 BLAST due | 5 | |
| Oct. 12 | Centrifugation / Ultracentrifugation - Sed. Velocity (s) slides | 5,13 | |
| Oct. 14 | Sedimentation Equilibrium / applications HW-2 | ||
| Oct. 19 | Light Scattering - static and dynamic slides / | 7 | |
| Oct. 21 | Circular Dichroism CD slides | 10 | |
| Oct. 26 | Mass Spectroscopy MS intro slides Review HW-2 due KEY | 15 | |
| Oct. 28 | ***** EXAM II **** Review Summary KEY NOTE: Exam in GSB 2.124 | ||
| Nov. 2 | MS Applications slides / | ||
| Nov. 4 | Ligand Binding - Introduction / equations KJ / kinetics | 2,14 | |
| Nov. 9 | Ligand binding ITC / Surface Plasmon Res SPR (SPR1, SPR2 ) WC due | 2,14 | |
| Nov. 11 | Intro. to the PDB, Image Formation notes / HW-3 | 6 | |
| Nov. 16 | X-ray Crystallography -1 notes | 6 | |
| Nov. 18 | X-ray Crystallography -2 notes | ||
| Nov. 23 | Nuclear Magnetic Resonance - notes / MRI / HW-3 due KEY | 12 | |
| Nov. 25 | ****** THANKSGIVING ****** | ||
| Nov. 30 | ***** EXAM III *** Note: Exam in UTC 2.112A Review Summary KEY | ||
| Dec 2 | Electron Microscopy - EM ; other imaging methods notes - Review Wrap Up / Final Exam Format and Sample / Sample Ans sheet and equations given | ||
| (Comp. Final is required unless you have a grade of A or B) | |||
| Dec 14 (Tu) | Comp. FINAL EXAM: 2:00-5:00 GAR 0.102 | ||
*September 23 - Last day to drop without possible academic penalty.
**October 20 - Last day undergraduates can drop a course for non-academic reasons, with the Dean's permission.
*HW-2: F - fv = m(dv/dt) solves to v = (F/f) [ 1 - exp(-ft/m)]. Calc. "s" for sed. velocity data and "M" from sedimentation equilibrium data.